Advertising is not a cancer. It helps offset costs for many of us.
However, the advertising on your site seems, at least as a guest, to be heavily modifying the content of the pages beyond what you likely intend or accounted for. This implementation of advertising, as it exists on the linked site, is a bit cancerous. It, like a cancer, overgrows its natural boundaries, is malignant to its environment, and spreads in such a way that it may be an impacting factor here.
Maybe not an issue for the target audience, and the feedback is not intended as a criticism or reflection on your decisions to monetize in this fashion, yet as you try to rule out what's going on, I'd test it with advertising disabled and on the default theme to see if the issues persist. Anything else is a stab in the dark. We don't know what's getting injected to load all those videos, popups, and other elements, nor where they are originating from.
On the standard theme, and on the theme here on this site, I don't see any issues with the ability to use reactions on a variety of mobile browsers.
Something additional in your implementation is likely the issue, whether that be a plugin/application, custom theme issue, or content inserted into the DOM by your ad networks, or some conflicting combination therein.