I've been able to correlate on one of my sites that shutting off zlib compression while on PHP 8.0.17 allows the site to come back on. I have all plugins apps disabled, tested with default theme. Turned zlib compression back on and the site goes down and blank white page. Turn it off, comes back online.
On another IPS site same server, I have zlib compression set to ON and running PHP 8.0.17 without issue. Shut it off/on, no issues. Very odd why one is ok and the other is not, same setup. I looked at caching/redis and if there are any differences. All my IPS sites are on the same server, same settings.
The site that is working is running: