I haven't seen any issues so far. The same issue could occur based on many instances running and not using cron but using members visiting the website to trigger it, like IPS on cloud.
For IPS with low to moderate traffic 2 micro instances are fine if you use S3, Elastic Search (I limited search to 250 results), Redis (underused on 4.4) and RDS services on the cloud (nano instances of these services are fine). Remember that is good to have a load balancer and more than one EC2 in different locations to assure that your community will be always online.
Yes, I use InnoDB on MariaDB on RDS. Sometimes I feel that it could be a little more faster for writing. For reading it is very fast.