So, you're going to be moderating 100 topics / posts on a daily basis?
Some thoughts (and I may be way off base on some of them, but hopefully this will get your creative juices flowing):
If these posts are in a certain board, then I think the easiest method would be to require Post Moderation. This can be applied per forum or per membergroup. You can then approve / manage the post approvals via the Moderator CP, which is designed to handle this use case.
If you're trying to moderate for keywords, then you can also use the keyword filter.
You create a private Activity Stream for yourself (or your moderators) that only shows Unread content. This will only show you ... unread content, which is kind of perfect, right?
I get all those.
I wonder, however, if IPS is going to have the same technical challenges as other requests from the community to make the Activity Stream interactive.