You'll have to manually open it with a database edit. For plugins just the 'disabled' and 'requires manual intervention' fields in the entry need adjusting (to zero); ditto for applications. You probably need to dump your datastore after making the manual edits.
Also, you are right @aXenDev, this current beta 5 still locks on upgrading. If they are making just an IN_DEV check, then yeah, it would still lock as we upgrade outside of dev mode. If IPS is actually checking for the -TESTINSTALL flag on the key, then it's just broken.
I suppose I'm lucky. Just one thing locked for me... that has been running on PHP 8 for a year. I'm more weirded out by all the log messages saying it can't parse the plugin directories as they think they are not there.
EDIT: The latter is caused by missing widget and tasks directories. They can change the log message for that to better indicate that is the problem rather than just say the plugin directory itself is the problem.
In 4.7.2 beta 4+ apps will no longer be locked disabled if you are using a development install.
Updating via uploading a new version or updating from the Marketplace should remove the lock. I will check this further to make sure it's working as expected.
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